Systems Biology of Fungal Infection
نویسندگان
چکیده
منابع مشابه
Systems Biology of Fungal Infection
Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi, Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the steadily increasing number of cases of invasive fungal infections. A key feature of these infections is the interaction of the different fungal morphotypes with epithelial and immune effector cells in the human host. Beca...
متن کاملSystems Biology of Microbial Infection
hOst-PathOgen InteractIOn In the past, most studies have focused on either the side of the pathogen or the host. Tierney et al. (2012) try to overcome this limitation using Next Generation Sequencing (RNA-Seq analysis) to monitor the gene expression of the host and the pathogen simultaneously. They analyze and model the interaction of mouse bone marrow-derived dendritic cells with the pathogeni...
متن کاملSystems biology of infectious diseases: a focus on fungal infections.
The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to fin...
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Abstract Background: Invasive fungal infection is an opportunistic infection caused commonly by mucoraccae and aspergillus. It mostly occurs in patients with underlying disease. Since it has a high mortality and morbidity rate, considering a treatment strategy seems necessary. Objective: Since there has not been a clear protocol for treating these patients, we decided to establish...
متن کاملFungal Genetics and Biology
Manual annotation of the Phytophthora ramorum and P. sojae genomes has identified 136, and 132 members, respectively, indicating that the ABC superfamily is comparable in size to the Arabidopsis and rice genomes. The high level of synteny that was observed between these oomycete genomes extends to the ABC superfamily where 107 orthologous pairs were identified by phylogenetic analysis. The larg...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2012
ISSN: 1664-302X
DOI: 10.3389/fmicb.2012.00108